New Random Integration Transgenic Animal Model Generation Solution Available
RENSSELAER, New York, Dec 4 (Bernama-GLOBE NEWSWIRE) -- Taconic Biosciences, a global leader in providing drug discovery animal model solutions, announces the launch of the new ExpressMODEL®: Random Integration Transgenic (RITg) service, which reduces animal model generation costs and timeline.
Many gene editing technologies are used to generate animal models for drug discovery, each with unique considerations but with the shared goal of creating specific genetic profiles. The technique used to generate RITg models produces an initial litter where the individual founder animals may or may not carry and/or express the intended genetic feature. Traditionally, each animal must be bred for several generations to determine which one(s) produce the desired outcome. This process adds considerable time and money to a project. In an industry compelled to reduce the timeline and cost of bringing new therapeutics to the world, ExpressMODEL®: RITg alleviates this burden.
Instead of breeding each founder animal and characterizing its offspring, ExpressMODEL®: RITg analyzes transgene expression and animal fertility in the first litter. This approach mitigates several risks inherent to RITg model generation. First, recognizing the successful animals earlier means resources are not wasted breeding animals with the incorrect genetic profiles. Second, obtaining the correct animals early in the process provides predictability for downstream activities. Since projects require intense coordination with other stakeholders and resources, this is extremely valuable. Third, customers can customize the final cohort size and animal health standard. Fourth, pursuing a smaller number of animals upfront reduces the overall number required for the project.
http://mrem.bernama.com/viewsm.php?idm=38862
No comments:
Post a Comment